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Lidocaine is one of the most controversial pharmacological agents in medicine. The mechanism by which lidocaine suppresses or exerts arrhythmic effects is still not well understood. Experimental studies have shown that the reduction of excitability provoked by lidocaine seems to contribute to arrhythmia, especially under ischaemic conditions, because external pH is decreased and the action of lidocaine on the sodium channel is increased, leading to a higher dispersion of conduction in the tissue. However, other studies support the antiarrhythmic behaviour of lidocaine, as a result of its ability to block spontaneous stimuli. By modelling the effects of Lidocaine on the sodium current, we will be able to conduct computer simulations at cellular, tissue and organ level, shedding light on the mechanisms of action of this drug and its role in arrhythmogenic processes.
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Last Updated on Monday, 01 March 2010 22:00 |
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SUMMARY
The three-year preDiCT project commenced in June 2008 and over the first 12 months has made excellent progress both scientifically and administratively in establishing itself as a collaborative community. The project has had extensive scientific outputs at major conferences and in well respected journals, and has disseminated its work through conference and workshop presentations. The project has made major progress in solidifying its links with the pharmaceutical industry through close interaction both with original industrial project partners and active engagement with new representatives who have subsequently joined our Scientific Advisory Board. We will continue this engagement through our specialist Pharma workshop in October 2009.
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Last Updated on Thursday, 22 October 2009 08:17 |
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Read more...
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Attached please find the preDiCT newsletter, published in January 2009. If you have dififculties downloading, please contact the Project Coordinator.
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Last Updated on Wednesday, 19 August 2009 11:30 |
The preDiCT project is one of several projects funded by the European Commission, as part of their support for the development of a Virtual Physiological Human, coordinated by the Virtual Physiological Human Network of Excellence (www.vph-noe.eu). Further information on our sister-projects can also be found on the CORDIS website.
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Last Updated on Wednesday, 24 September 2008 13:52 |
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