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Please contact Katherine Fletcher for a .pdf copy of the latest preDiCT newsletter.  (click title to read newsletter online)

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The preDiCT project - is one of several projects funded by the European Commission, as part of their support for the development of a Virtual Physiological Human.

About the preDiCT project PDF Print E-mail

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Last Updated on Friday, 20 May 2011 11:19
 
Real-World Applications

 

Dofetilide hERG block on ECG - Nejib - Dec 2010

Last Updated on Friday, 20 May 2011 11:18
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Project Results PDF Print E-mail

Now at the end of its three-year mission, the preDiCT project has made major advances in:

  • Predicting risk of Torsades-de-Pointes (a dangerous cardiac side effect which is a major focus for drug safety testing);
  • Linking together models from subcellular to whole-body scale, to give insight into how a drug’s action on an ion channel can translate to disturbances in heart rhythm;
  • Creating an easy-to-use environment for running models, to enable non-expert users to benefit from preDiCT’s techniques.

Beyond the life of the project, our research will continue, including collaborations with GSK (investigating TdP risk stratification), Astra Zeneca (modelling of atrial fibrillation), Johnson&Johnson (modelling for insight into drug actions), and the US FDA (modelling for development of new devices).  The wider Virtual Physiological Human movement is still underway and preDiCT researchers anticipate new collaborations with researchers in our sister-projects and beyond.

Attached to this document, you can find a Guide to Models used by the project, an explanation of the TdP risk prediction technique, and an overview of a meeting with industry regulators convened by the project.

Last Updated on Wednesday, 08 June 2011 11:06
 

This project is partly funded by the European Commission.

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